# S7-Major Milestones

By [Big Bang Theory Fans](https://dylit.info/user/bigbangtheoryfans)

[Big Bang Theory](https://dylit.info/presence/Big-Bang-Theory/69442e7d871bdbf5e05799b4) > [S7-Major Milestones](https://dylit.info/channel/S7-Major-Milestones/6963e26191dd956ce475f9ee)

Episode 21: The Isolation Permutation Sheldon feels left out when everyone pairs off for dates. Howard faces comic book store management challenges while Leonard supports Penny's acting career. Bernadette deals with pharmaceutical work stress while Amy analyzes Sheldon's social isolation scientifically.